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KMID : 1036520170070010014
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Clinical Neuro-Ophthalmology
2017 Volume.7 No. 1 p.14 ~ p.16
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Ophthalmoplegia Associated with Anti-ganglioside Antibody
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Choi Seo-Young
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Abstract
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Anti-ganglioside antibody is the well-known cause for Guillain-Barre syndrome, which is the autoimmune disease characterized by limb weakness and areflexia. Since some lipopolysaccarides of Campylobacter jejuni have ganglioside-like epitopes, the autoimmune antibodies attack the peripheral and maybe, central nervous system. Miller Fisher syndrome characterized by ophthalmoplegia, ataxia, and areflexia is the most common variant form of Guillain-Barre syndrome. Anti-GQ1b antibody is specific to this syndrome, especially, ophthalmoplegia, because GQ1b is located on the perinodal area of the ocular motor nerves. Variable epitopes from the complex form of anti-ganglioside antibodies can induce the broad clinical spectrum of anti-GQ1b syndrome.
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KEYWORD
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Anti-ganglioside antibody, Ophthalmoplegia, Anti-GQ1b antibody, Miller Fisher syndrome
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